北京师范大学放射性药物教育部重点实验室
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张俊波


教授,博士生导师,理学博士(北京师范大学)
通信地址:北京市新街口外大街19号 北京师范大学化学学院
邮编:100875
电话:010-58802740; 传真:010-62208126
电子邮箱: zhjunbo@bnu.edu.cn

一 个人简介

     张俊波,男,1971年9月出生,理学博士,教授,博士生导师。现任北京师范大学化学学院副院长。目前以第一作者或通讯作者发表SCI论文40篇,作为第一发明人获得国家发明专利授权25项。主持4项国家自然科学基金,3项北京市科技项目和1项中央高校基本科研业务费专项资金重点项目,作为骨干参加国家和省部级科研项目10项。以第一完成人获得了2002年北京师范大学优秀科技成果奖,连续2次获得北京师范大学第六届、第七届励耘奖学助学基金优秀学术著作二等奖。2004年入选北京市科技新星计划和北京市优秀人才培养计划。2005年被评为北京市优秀德育工作者。2006年获得北京师范大学第八届励耘奖学助学基金优秀青年教师二等奖。2007年当选为中国核学会核化学与放射化学分会第八届委员会委员、副秘书长。2008年获首届肖伦青年科技奖。2009年获得中华医学会第八届全国核医学学术会议优秀论文竞赛优胜奖和中国核学会学术年会优秀论文一等奖。目前是《核化学与放射化学》、《Pharmacy Information药物资讯》、《Hans Journal of Biomedicine 生物医学》、《Journal of Bacteriology and Mycology》、《International Journal of Radiology》期刊编委,近年来先后担任药物化学领域国际知名期刊《Current Pharmaceutical Design》和 《Current Medicinal Chemistry》的Executive Guest Editor。

 
二 科研方向

    研究方向为放射性药物化学,主要从事单光子发射(SPECT)和正电子发射(PET)诊断药物以及放射性治疗药物的设计合成以及开发应用研究,其中以新型心、脑、肿瘤以及炎症等放射性分子探针为重点研究目标。

三 主持和承担项目

国家自然科学基金项目(项目编号:20201004, 经费:20万; 起止时间:03.1-05.12)
北京市科技新星计划项目(项目编号:2004A20, 经费:7万; 起止时间:04.7-07.7)
北京市优秀人才培养项目(项目编号:20042D0503101, 经费:3万;起止时间:05.01-07.1)
国家自然科学基金项目(项目编号:20771018, 经费:28万; 起止时间:2008.1-2010.12)
放射化学与辐射化学国防重点学科实验室开放课题(项目编号:2010-06, 经费:2万;起止时间:2011.01-2011.12)
北京市教育委员会科技成果转化与产业化项目(项目编号:403103,经费:15万;起止时间:2011.01-2011.12)
北京市自然科学基金项目(项目编号:7112035 经费:11万;起止时间:2011.01-2013.12)
中央高校基本科研业务费专项资金重点项目(项目编号:105566 经费:35万;起止时间:2011.01-2013.12)
国家自然科学基金项目(项目编号:21171024 经费:60万;起止时间:2012.01-2015.12)
北京市科技新星计划交叉学科合作项目(项目编号:xxhz201306 经费:10万; 起止时间:2013.07—2014.07)
国家自然科学基金项目(项目编号:21541001  经费:10万;起止时间:2016.01-2016.12)

四 以第一作者或通讯作者发表SCI文章与授权的国家发明专利

1) Zhenxiang Li , Xiao Lin, Junbo Zhang*, XuebinWang, Zhonghui Jin*,Weifang Zhang, Yanyan Zhang. Kit formulation for preparation and biological evaluation of a novel 99mTc-oxo complex with metronidazole xanthate for imaging tumor hypoxia. Nuclear Medicine and Biology, 2016, 43, 165-170.

2) Zhenxiang Li, Junbo Zhang*, Zhonghui Jin*,Weifang Zhang, Yanyan Zhang. Synthesis and biodistribution of novel 99mTc labeled 4-nitroimidazole dithiocarbamate complexes as potential agents to target tumor hypoxia. MedChemComm, 2015, 6, 1143-1148.

3) Zhenxiang Li , Xiaoqing Song, Junbo Zhang*. Synthesis and biological evaluation of novel 99mTc labeled ornidazole xanthate complexes as potential hypoxia imaging agents. Journal of Radioanalytical and Nuclear Chemistry, 2015, 306, 535-542.

4) Yue Wang, Xiaoqing Song, Junbo Zhang*. Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor. Journal of Radioanalytical and Nuclear Chemistry, 2015, 306, 477-482.

5) Junbo Zhang. Current Status and progress of radiopharmaceuticals for molecular imaging and targeted therapy. Current Medicinal Chemistry, 2014, 21(1): 2-3.

6) Teli Liu, Junbo Zhang*, Xuebin Wang, Jigang Yang, Zhigang Tang, Jie Lu. Radiolabeled glucose derivatives for tumor imaging using SPECT and PET. Current Medicinal Chemistry, 2014, 21(1): 24-34.

7) Yue Wang, Jingjing Zhu, Xiaoqing Song, Xuebin Wang, Jigang Yang and JunboZhang*. Synthesis and evaluation of 99mTc-2-[(3-carboxy-1-oxopropyl)amino]-2-deoxy-D-glucose as a potential tumor imaging agent. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3882-3885.

8) Xiao Lin , Xiaoyu Chao , Junbo Zhang*, Zhonghui Jin,Yanyan Zhang. Preparation and biodistribution of a 99mTc tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3964-3967.

9) Jingjing Zhu, Yue Wang, Zhenxiang Li, Si’an Fang, Junbo Zhang*. Synthesis and biological evaluation of novel 99mTc-oxo and 99mTc-nitrido complexes with phenylalanine dithiocarbamate for tumor imaging. Journal of Radioanalytical and Nuclear Chemistry, 2014, 302,211-216.

10) Miao Liu, Xiao Lin, Xiaoqing Song, Yang Cui, Peiwen Li, Xuebin Wang, Junbo Zhang*. Synthesis and biodistribution of a novel 99mTc nitride radiopharmaceutical with proline dithiocarbamate as a potential tumor imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2013, 298(3), 1659-1663.

11) Junbo Zhang. Recent advance in the development of radiolabeled in vivo probes for diagnosis and therapy. Current Pharmaceutical Design, 2012, 18(8): 1021-1022.

12) Xiao Lin, Junbo Zhang*, Xuebin Wang, Zhigang Tang, Xianzhong Zhang, Jie Lu. Development of radiolabeled compounds for myocardial perfusion imaging. Current  Pharmaceutical Design, 2012, 18(8): 1041-1057.

13) Xiao Lin, Zhonghui Jin, Jialei Ren, YanPang Weifang Zhang, Jinfeng Huo, Xuebin Wang, Junbo Zhang,*  Yanyan Zhang*. Synthesis and biodistribution of a new 99mTc-oxo complex with deoxyglucose dithiocarbamate for tumor imaging. Chemical Biology & Drug Design, 2012, 79: 239-245.

14) Shijian Zhang, Weifang Zhang, Yue WangZhonghui Jin, Xuebin Wang, Junbo

Zhang*, Yanyan Zhang*. Synthesis and biodistribution of a novel 99mTcN complex of norfloxacin dithiocarbamate as a potential agent for bacterial infection imaging. Bioconjugate Chemistry, 2011, 22: 369-375.

15Junbo Zhang*, Shijian Zhang, Haixun Guo, XueBin Wang. Synthesis and biological evaluation of a novel 99mTc(CO)3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection. Bioorganic & Medicinal Chemistry Letters, 2010, 20, 3781-3784.

16Junbo Zhang*, Xiao Lin, Jialei Ren, Jing Liu, XueBin Wang. Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging. Applied Radiation and Isotopes, 2010, 68, 101-104.

17Junbo Zhang*, Qian Yu, Jinfeng Huo, Yan Pang, Sheng Yang, Yining He, Tingting Tang, Chenchen Yang, Xuebin Wang. Synthesis and biodistribution of a novel Tc-99m-DMSA-metronidazole ester as a potential tumor hypoxia imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2010, 283(2), 481-485.

18Junbo Zhang*, Jialei Ren, Xiao Lin, XueBin Wang. Synthesis and biological evaluation of a novel 99mTc nitrido radiopharmaceutical with deoxyglucose dithiocarbamate, showing tumor uptake. Bioorganic & Medicinal Chemistry Letters, 2009, 19(10), 2752-2754.

19) Junbo Zhang*, ZhiXin Song, Jinfeng Chu, XueBin Wang. Synthesis and biodistribution of a novel [99mTcN(PNP5)( DMCHDTC)]+ complex as a potential myocardial perfusion imaging agent. Applied Radiation and Isotopes, 2009, 67, 1661-1663.

20) Junbo Zhang*, Yan Lin, Xi Sheng, XueBin Wang. Synthesis of a novel 99mTc nitrido radiopharmaceutical with isopropyl xanthate, showing brain uptake. Applied Radiation and Isotopes, 2009, 67, 79-82.

21) Junbo Zhang,* ZhiXin Song, XueBin Wang. Synthesis of a bis(2,3-dimethylcyclohexyldithiocarbamato)  nitrido 99mTc complex: a potential tracer for myocardial imaging. Applied Radiation and Isotopes, 2009, 67, 577-580.

22) Junbo Zhang,* Gang Luo, XueBin Wang. Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing ether group as a potential myocardial and brain imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2009, 279(3), 783-785.

23) Junbo Zhang *, Haixun Guo, Shijian Zhang, Yan Lin, Xuebin Wang. Synthesis and biodistribution of a novel 99mTcN complex of ciprofloxacin dithiocarbamate as a potential agent for infection imaging. Bioorganic & Medicinal Chemistry Letters, 2008, 185168-5170.

24) Haixun Guo, Junbo Zhang*, Zhiwei Ma, Xuebin Wang. Synthesis and biodistribution of 99mTcN-isopentyl xanthate as a potential myocardial perfusion imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2008, 275(1), 121-123.

25) Junbo Zhang*, TianJun Yu, ZhongFang Wang, Yan Lin, Fang Wen, MiaoMiao Xing, XueBin Wang. Synthesis and biodistribution of two novel 99mTc nitrido dithiocarbamate complexes containing heterocyclic linkage as potential brain perfusion imaging agents. Journal of Radioanalytical and Nuclear Chemistry, 2007, 274(1)195-197.

26) Junbo Zhang*, Xuebin Wang, Can Jin. Synthesis and biodistribution of the 99mTc(CO)3-DEDT complex as a potential new radiopharmaceutical for brain imaging. Journal of Radioanalytical and Nuclear Chemistry, 2007, 272(1), 91-94.

27)Junbo Zhang*, Xuebin Wang, ChunJun Tian. Synthesis of a bis-(N-butyl-dithiocarbamato)-nitrido 99mTc complex: a potential new brain imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2007, 273(1), 15-17.

28)Junbo Zhang*, Xuebin Wang, Can Jin.Synthesis of 99mTc(CO)3-NOET via [99mTc(OH2)3(CO)3]+ precursor and comparative biological studies with 99mTcN-noet. Journal of Radioanalytical and Nuclear Chemistry, 2006, 269(1), 227-230.

29)Junbo Zhang*, Xuebin Wang, Jing Liu. Synthesis of a bis-(N-sec-butyl-dithiocarbamato)-nitrido-99mTc complex: a potential new radiopharmaceutical for brain perfusion studies. Applied Radiation and Isotopes, 2005, 62:33-37.

30Junbo Zhang*, Xuebin Wang, Chunjun Tian. Synthesis and biodistribution of 99mTcN(PDTC)2 as a potential brain imaging agents. Journal of Radioanalytical and Nuclear Chemistry, 2004, 262:505-507.

31) Junbo Zhang*, Xuebin Wang,Jing Liu. Synthesis and biodistribution in mice of a new 99mTc nitrido complex for brain imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 2004, 47:647-655.

32Junbo Zhang, Xuebin Wang, Chunyun Li. Synthesis and biodistribution of a new 99mTc nitrido complex for cerebral imaging. Nuclear Medicine and Biology, 2002, 29(6), 665-669.

33) Junbo Zhang*, Xuebin Wang, Chunyun Li. Synthesis and biodistribution of 99mTcN(CHIPDTC)2 as a potential myocardial perfusion imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2002, 254(1), 99-101.

34Junbo Zhang*, Xuebin Wang, Chunyun Li. Synthesis and biodistribution of a new 99mTc nitrido complex as a potential myocardial and cerebral imaging agent. Applied Radiation and Isotopes, 2002, 56, 857-861.

35) Junbo Zhang*, Xuebin Wang. Preparation of 99mTcN(CBTDC)2 and its biodistribution in mice. Applied Radiation and Isotopes, 2001, 55(4), 453-456.

36) Junbo Zhang*, Xuebin Wang. Synthesis and biodistribution of the 99mTcN-DMSA complex as a potential bone imaging agent. Journal of Radioanalytical and Nuclear Chemistry, 2001, 249(3), 523-525.

37) 张俊波*,王学斌.一种新型脑灌注显像剂99mTcN-CPDTC的制备及其生物分布研究。高等学校化学学报, 2001, 22(7), 1095-1097.

38)Junbo Zhang*, Xuebin Wang. Synthesis of 99mTcN(IPDTC)2 and its biodistribution in mice. Journal of Radioanalytical and Nuclear Chemistry, 2001, 249(3), 573-576.

39) Junbo Zhang*, Xuebin Wang, Gongxu Lu, Zhigang Tang. Synthesis and biodistribution of a new 99mTc nitrido complex for brain imaging. Applied Radiation and Isotopes2001, 54,745-748.

40) Junbo Zhang*, Xuebin Wang, Gongxu Lu, Zhigang Tang. Synthesis, characterization and biodistribution of a 99mTc nitrido complex as a potential brain perfusion imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 2000, 43, 693-700.

授权国家发明专利:

1) 张俊波,王学斌。一种脑灌注显像剂99mTcN(CHDT)2及其制备方法,专利号:99109699.1,    授权公告日:2002-07-17

2) 张俊波,王学斌,李春云。99mTcN二巯基丁二酸类化合物,其制备方法和其在核医学上的应用, 专利号:02156871.5, 授权公告日:2005-12-21

3) 张俊波,王学斌,刘婧。99mTcN二硫代氨基甲酸盐类化合物,其制备方法和其在核医学上的应用,专利号:02158757.4, 授权公告日:2006-01-04

4)  张俊波, 王学斌,陆洁,唐志刚。 99mTcN(CPEDTC)2配合物作为肿瘤显像剂在核医学领域中的应用,专利号:2005101347053, 授权公告日:2008-01-23

5) 张俊波, 郭海勋, 林艳, 张仕坚, 王学斌, 唐志刚, 张现忠, 陆洁。 99mTcN核标记氨荒酸盐配合物、其制备方法及其应用, 专利号:200710146035.6, 授权公告日:2010-11-10

6) 张俊波, 郭海勋, 张仕坚, 林艳, 王学斌, 唐志刚, 张现忠, 陆洁。 99mTcN核标记环丙沙星氨荒酸盐配合物及制备方法和应用,专利号:200810106153.9, 授权公告日:2010-12-01

7)  张俊波, 任佳蕾,王学斌, 唐志刚, 张现忠, 陆洁。一种 99mTcN(DGDTC)2配合物及其制备方法和应用,专利号:200810239503.9, 授权公告日:2010-12-22

8) 张俊波,张仕坚,郭海勋,王学斌, 唐志刚,张现忠, 陆洁。99mTc(CO)3环丙沙星氨荒酸盐配合物及制备方法和应用, 专利号:200910078116.6, 授权公告日:2011-01-12

9) 张俊波, 于倩,杨胜,何艺宁,唐亭婷,杨琛琛,王学斌, 唐志刚, 张现忠, 陆洁。 99mTc标记二巯基丁二酸甲硝唑酯类配合物及制备方法和应用专利号:200810239502.4, 授权公告日:2011-09-07

10) 张俊波,于倩,刘青,杨胜,何艺宁, 唐亭婷,杨琛琛,王学斌, 唐志刚, 张现忠, 陆洁。99mTcN核标记硝基咪唑类黄原酸盐配合物及制备方法和应用专利号:200910078115.1, 授权公告日:2011-04-13

11) 张俊波,林潇,任佳蕾,王学斌, 唐志刚, 张现忠, 陆洁。一种99mTc-EDTA-MTI配合物的制备方法和应用专利号:200910083367.3, 授权公告日:2011-09-07

12) 张俊波,任佳蕾,林潇,王学斌, 唐志刚, 张现忠, 陆洁。99mTcO核标记D-葡萄糖氨荒酸盐配合物及其制备方法和应用专利号:200910084555.8, 授权公告日:2011-06-29

13) 张俊波,于倩,刘青,王学斌, 唐志刚, 张现忠, 陆洁。99mTcO核标记硝基咪唑类黄原酸盐配合物及制备方法和应用专利号:200910084554.3, 授权公告日:2011-03-30

14) 张俊波,张仕坚,王跃,王学斌, 唐志刚,张现忠, 陆洁。一种99mTcO核标记环丙沙星氨荒酸盐配合物及制备方法和应用, 专利号:200910086894.X, 授权公告日:2011.09.28

15) 张俊波,任佳蕾,林潇,马志伟,王学斌, 唐志刚, 张现忠, 陆洁。一种99mTc标记柔红霉素氨荒酸盐配合物及制备方法和应用专利号:200910086895.4, 授权公告日:2011-06-08

16) 张俊波,张仕坚,王跃,王学斌, 唐志刚,张现忠, 陆洁。一种99mTcN(NFXDTC)2配合物及其制备方法和应用, 专利号:200910180489.4, 授权公告日:2011.12.07

17) 张俊波,霍金凤,李贞翔,张仕坚,王学斌, 唐志刚,张现忠, 陆洁。99mTc标记2-硝基咪唑类黄原酸盐配合物的制备方法和应用, 专利号:201010581698.2, 授权公告日: 20120919日。

18)张俊波,晁小雨,张仕坚,霍金凤,王学斌, 唐志刚,张现忠, 陆洁。一种99mTc(CO)3-DGDTC配合物及其制备方法和应用,专利号:201010581671.3, 授权公告日:20120725日。

19张俊波,刘淼,霍金凤,林潇,张仕坚,王学斌,唐志刚,张现忠,陆洁。 99mTcO核标记美法仑氨荒酸盐配合物及制备方法和应用,专利号:201110049962.2, 授权公告日:20130807日。

20张俊波,王跃,张仕坚,霍金凤,王学斌,唐志刚,张现忠,陆洁。一种99mTc标记D-葡萄糖配合物的制备方法及应用,专利号:201110049973.0, 授权公告日:20130807日。

21) 张俊波, 刘淼,林潇,李贞翔,王学斌,唐志刚,张现忠,陆洁。 99mTcO核标记蛋氨酸氨荒酸盐配合物的制备方法和应用, 专利号:201210358983.7,  授权公告日:20150114日。

22) 张俊波, 刘特立,卢忠林,阎浩,陆洁,王学斌, 唐志刚。一种99mTc(CO)3核标记大环多胺三唑环类葡萄糖基配合物及其制备方法和应用,专利号:201210552016.4, 授权公告日:20150422日。

23) 张俊波, 王跃,朱菁菁,陆洁,王学斌, 唐志刚。99mTc标记的葡萄糖类衍生物及其制备方法和应用,专利号:201210551831.9, 授权公告日:20150513日。

24) 张俊波, 王跃, 张站斌,卜昕,王学斌, 唐志刚, 关淑贞。 一种用于盐酸奈必洛尔合成质量控制的检测分析方法,专利号:201410123241.5, 授权公告日:20150930日。

25) 张俊波,李贞翔,陆洁,罗超慧,王学斌, 唐志刚。一种99mTcO(MNXT)2配合物及其制备方法和应用,专利号:201210551884.0, 授权公告日:20151125日。

 

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