个人简介

张华北，博士, 北京师范大学教授，博士生导师。 现任放射性药物教育部重点实验室副主任，中国核学会核化学与放射化学学分会副主任委员， 中国化学会核化学与放射化学专业委员会副主任，北京核学会核医学和分子影像专委会副主任委员， 《，中国核学会同位素分会常务理事，中国同位素与辐射行业协会专家咨询委员会委员，核化学与放射化学》杂志副主编， 《同位素》杂志副主编。张华北是放射性药物教育部重点实验室主要学术带头人之一，长期从事药物设计、合成、标记和生物性质评价。 正式发表论文90多篇(除少数几篇之外均为第一作者或通讯作者), 其中许多文章发表在J. Med. Chem.，Curr. Med. Chem.，Curr. Pharm. Des.等国外重要杂志上，授权国家科技发明专利多项。主持国家16个重大科技专项《重大新药创制》国家重大科技专项、国家科技支撑课题以及国家自然科学基金多项。 张华北在中国科学院组织的《放射化学咨询报告》中担任放射性药物部分的负责人和主要撰稿人,该报告得到温家宝总理和刘延东副总理的重要批示，主要负责起草的《关于加强放射性药物研发的建议》得到了我国34位两院院士的签名支持。张华北还是国家自然科学基金委组织的《无机化学学科前沿与展望》一书放射化学部分的负责人和主要撰稿人。在第八届中日双边放射性药物会议（2010年，北京）和第十二届全国放射性药物与标记化合物会议（2014年，合肥）担任大会组委会执行主席。

研究兴趣

博士研究生：招生专业是药物化学与分子工程，研究方向是计算机辅助药物分子设计与药物合成

硕士研究生：药物化学，研究方向是药物分子设计与合成

研究领域

主持的项目

张华北发表的部分文章

1. Zeng HH， Zhang HB*，Synthesis and biological evaluation of fatty acids conjugates bearing cyclopentadienyl-donors incorporated [(99m)Tc/Re(CO)3](+) for myocardical imaging， Eur. J. Med. Chem.  2014，24(72):10-7
2. Yu  HJ, Fang Y, Lu X,  Liu YJ,  Zhang HB*，Combined 3D-QSAR, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation Studies on the 5-Hydroxy-2H-Pyridazin-3-One Derivatives as HCV NS5B Polymerase Inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN ，2014, 83: 89-105
3. Zeng HH, Zhao LZ, Hu SY, Liu YJ, Yu HJ, Chen N, Zhang HB*.,Synthesis, characterization and biodistribution of new fatty acids conjugates bearing N,N,N-donors incorporated [(99m)Tc/Re(CO)(3)](+),  Dalton Trans.  2013, 42(8):2894-901.
4. Lu X, Zhao LZ, Xue T, Zhang HB*, Technetium-99m- Arg-Arg-Leu(g2), a modified peptide probe targeted to neovascularization in molecular tumor imaging, J BUON.  2013 ;18(4):1074-81.
5. Hu S, Yu H, Liu Y, Xue T, Zhang H. Insight into the binding model of new antagonists of kappa receptor using docking and molecular dynamics simulation. J Mol Model.  2013，19(8):3087-94.
6. Zeng HH, Zhang HB, Wu XX, Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium-99m fatty acid derivative for myocardical imaging, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS ，2013，56(1): 1-5.
7. Liu YJ, Yu HJ, Zhao, LZ, Zhang HB*, Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging, NUCLEAR MEDICINE AND BIOLOGY,2013, 40(1): 126-134 
8. Liu YJ, Yu HJ, Zhao, LZ, Zhang HB*,Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging, NUCLEAR MEDICINE AND BIOLOGY 40(1): 126-134,2013.
9. Zhao, Lingzhou; Liu, Yongjuan; Hu, Shiyuan; ZhangHB* , 3D-QSAR study of Chk1 kinase inhibitors based on docking, JOURNAL OF MOLECULAR MODELING, 2012,18(8): 3669-3694
10. Chen Na; Liu Chunkai; Zhao Lingzhou, Zhang Huabei*, 3D-QSAR study of multi-target-directed AchE inhibitors based on autodocking, MEDICINAL CHEMISTRY RESEARCH, 21(2): 245-256,2012
11. Zeng H, Zhang H, Jang F, Zhao L, Zhang J. Molecular Modeling Studies on Benzimidazole Carboxamide Derivatives as PARP-1 Inhibitors Using 3D-QSAR and Docking, Chem Biol Drug Des. 2011,78(3):333-52.
12. Zeng Huahui; Zhang Huabei，Domestic Advances in Brain, Heart, and Tumor Radioactive Diagnosis Drugs，PROGRESS IN CHEMISTRY，2011，23（7）: 1485-1492  
13. Yang Yang; Zhu Lin; Chen Xiangji，Binding research on flavones as ligands of beta-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies， JOURNAL OF MOLECULAR GRAPHICS & MODELLING  ，2010，29( 4): 538-545  
14. Yang Y, Zhu L, Cui MC, Tang RK, Zhang HB*  Preparation of classical Re/Tc-99m(CO)(3)(+) and novel Tc-99m(CO)(2)(NO)(2+) cores complexed with flavonol derivatives and their binding characteristics for A beta((1-40)) aggregates，BIOORGANIC & MEDICINAL CHEMISTRY LETTERS，2010， 20（ 17）: 5337-5344  
15. Zeng HH, Zhang HB*，Combined 3D-QSAR modeling and molecular docking study on 1,4-dihydroindeno[1,2-c]pyrazoles as VEGFR-2 kinase inhibitors， JOURNAL OF MOLECULAR GRAPHICS & MODELLING，2010, 29（1）， 54-71， 2010
16. Cao R, Mi N, Zhang H*. 3D-QSAR study of c-Src kinase inhibitors based on docking. J Mol Model. 2010，16(2):361-75.
17. Yang Y, Zhang JX, Zhu L, Zhang H*   Synthesis, Novel Crystal Structure, and beta-Amyloid Binding Property of Re(I) (tricarbonyl) EHIDA Analogue Bioinorg Chem Appl. 2009:702730.
18. Cao R, Mi N, Zhang H*.,3D-QSAR study of c-Src kinase inhibitors based on docking.J Mol Model. 2010 Feb;16(2):361-75.
19. Yang Y, Zhu L, Zhang HB*.   Di-tert-butyl 2,2'-[(2-hydroxyethyl)azanediyl] diacetate ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE  2009，65（12）3167-U1248.
20. Cao R, Zeng H, Zhang H*.，3D-QSAR studies on a series of inhibitors docked into a new homology model of the DNA-PK receptor. Curr.  Pharm.  Des. 2009; 15(32): 3796-825.
21. Cao HY, Cao R, Zhang HB*, Zheng XF, Gao DB，Non-nucleoside Inhibitors of NS5B Polymerase Binding to Allosteric Sites: 3D- QSAR and Molecular Docking Studies，Curr. Med. Chem., 2008，15: 1462-77.
22. Zhang HB*, Hu SP, Zhang YL. Prediction of distribution of neutral, acidic and basic structurally diverse compounds between blood and brain by the nonlinear methodology. Med Chem. 2008 , 4:170-89.
23. Zhang HB*, Li H, Ma QQ QSAR study of a large set of 3-pyridyl ethers analogues，Journal of Molecular Graphics and Modelling, 2007,  26: 226-235.
24. Cao HY, Zhang HB*，Zheng XF, Gao DB，3D QSAR studies on a series of potent and high selective inhibitors for three kinases of RTK family，Journal of Molecular Graphics and Modelling, 2007, 26:236-245.
25. Zhang HB*, Zhang YL,  Convenient Nonlinear Model for Predicting the Tissue/Blood Partition Coefficients of Seven Human Tissues of Neutral, Acidic and Basic Structural-Diverse Compounds, J. Med. Chem., 2006，49:, 5815-5829.
26. Zhou JM, Zhou JH, Zhang HB, et al. Fluoro-substitution effects in deoxyfluoro-D-glucose derivatives: random conformational search and quantum chemical calculation , CARBOHYDRATE RESEARCH, 2006, 341: 2224-2232.
27. Zhang HB*, A QSAR Study of the Brain/Blood Partition Coefficients on the Basis of  pKa Values, QSAR & combinary chemistry, 2006, 25:, 15-24.
28. Zhang HB*, Li H, Liu CP，CoMFA, CoMSIA and Molecular Hologram QSAR Studies of Novel Neuronal nAChRs Ligands – Open Ring Analogues of 3-pyridyl Ether，J. Chem. Inf. model. 2005, 45: 440-448.
29. Zhang HB*, Ye HH,  Zhang YL , et al.Synthesis, biodistribution and QSAR studies of five Tc-99m labeled novel N3S pseudo-peptide complexes， Med. Chem. Res. 2005, 14: 40-56.
30. Zhang HB*, A new approach for the tissue-blood partition coefficients of neutral and ionized compounds, J. Chem. Inf. model. 2005, 45:121-127. 

部分发明专利：