贾红梅

个人简介

教授，博士生导师，理学博士（北京师范大学），美国耶鲁大学访问学者，德国亥姆霍兹Dresden‒Rossendorf研究中心高级研究学者，德国莱比锡多学科综合同位素研究院访问学者和高级访问学者。国际同位素学会(IIS)官方期刊《Journal of Labelled Compounds and Radiopharmaceuticals》的亚洲编辑、国际放射性药物科学学会(SRS)官方期刊《Nuclear Medicine and Biology》和欧洲期刊《EJNMMI Radiopharmacy and Chemistry》编委等。

通信地址：北京市新街口外大街19号 北京师范大学化学学院

邮编：100875

电话：010 5880 7843； 传真：010 5880 2750

电子邮箱: hmjia@bnu.edu.cn

讲授课程

放射性药物化学，普通化学实验

研究兴趣

放射性药物化学，生物功能显像分子探针的研究。

主持的科研项目

1. 针对神经炎症的靶向小胶质细胞集落刺激因子1受体的PET显像分子探针研究，2023.1-2026.12，国家自然科学基金项目（22276016）；

2. 用于阿尔茨海默病诊断和治疗效果评价的sigma-2受体分子探针，2019.1-2022.12，国家自然科学基金项目（21876013）；

3. 18F标记的sigma-1受体分子探针和阿尔茨海默病进程中的可视化研究，北京市自然科学基金项目（7212203）；

4. 用于肿瘤诊断和个性化治疗的Tc-99m/Re-188标记的s2受体放射性药物研究，2015.1−2018.12，国家自然科学基金项目（21471019）；

5. Tc-99m标记的s2受体肿瘤分子探针的研究，2010.1−2013.12，国家自然科学基金项目（21071023）；

6. Tc-99m标记的s受体肿瘤显像剂的研究，2006.1−2008.12，国家自然科学基金项目（20501004）；

7. 还原醚化反应及其在F-18标记的PET放射性药物合成中的应用研究，教育部留学回国人员科研启动基金；

8. 肿瘤显像与治疗，2013.4−2013.10，国家自然科学基金国际合作与交流项目（21310102012）；

9. Sigma受体分子探针的研究，2011.10−2011.11，国家自然科学基金国际合作与交流项目（21110102042）；

10. Sigma受体显像剂的研究，2008.10.19−2008.10.26，国家自然科学基金国际合作与交流项目（20810102039）；

11. Sigma受体显像剂的生物评价方法，2007.10，国家自然科学基金国际合作与交流项目。

专利

1. 贾红梅、何颖芳、谢芳、陆洁、黄艺耘。结合sigma-1受体的四羟基糠基哌嗪类化合物、其制备方法及应用。中国，专利号ZL 2016 1 0509926.2。授权公告日：2018年10月23日。

2. 贾红梅，王霞，李丹，崔孟超，刘伯里. 结合sigma-1受体的三羰基环戊二烯类配体化合物、其制备方法及应用. 专利号: ZL 2013 1 0339656.1授权公告日：2016年4月6日.

3. 贾红梅，李艳，张锦明，崔孟超，刘伯里. 氟-18标记的螺环哌啶类sigma-1受体化合物及制备方法和应用. 专利号: ZL 2012 1 0097119.6. 授权公告日：2014年10月08日.

代表性论文

1. Zhang Ying, Wang Tao, Zhang Xiaojun, Deuther-Conrad Winnie, Fu Hualong, Cui Mengchao, Zhang Jinming*, Brust Peter, Huang Yiyun*, Jia Hongmei*. Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors. Acta Pharmaceutica Sinica B, 2022, 12(3): 1406-1415.

2. Wang Tao, Zhang Ying, Zhang Xiaojun, Chen Leyuan, Zheng Ming-Qiang, Zhang Jinming*, Brust Peter, Deuther-Conrad Winnie, Huang Yiyun*, Jia Hongmei*. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP. Chinese Chemical Letters, 2022, 33(7): 3543-3548.

3. Jia Hongmei*, Cai Zhengxin, Holden Daniel, He Yingfang, Lin Shu-fei, Li Songye, Baum Evan, Shirali Anupama, Kapinos Michael, Gao Hong, Ropchan Jim, Huang Yiyun*. Positron emission tomography imaging evaluation of a novel 18F-labeled sigma-1 receptor radioligand in cynomolgus monkeys. ACS Chemical Neuroscience, 2020, 11: 1673−1681.

4. Tian Jiale, He Yingfang, Deuther-Conrad Winnie, Fu Hualong, Xie Fang, Zhang Ying, Wang Tao, Zhang Xiaojun, Zhang Jinming*, Brust Peter, HuangYiyun, Jia Hongmei*. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry, 2020, 28: 115560.

5. He Yingfang, Xie Fang, Ye Jiajun, Deuther-Conrad Winnie, Cui Bixiao, Wang Liang, Lu Jie, Steinbach Jörg, Brust Peter, Huang Yiyun, Lu Jie*, Jia Hongmei*. 1-(4-[18F]Fluorobenzyl)-4-((tetrahydrofuran-2-yl) methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain. Journal of Medicinal Chemistry, 2017, 60: 4161-4172.

6. Wang Liang, Ye Jiajun, He Yingfang, Deuther-Conrad Winnie, Zhang Jinming, Zhang Xiaojun, Cui Mengchao*, Steinbach Jörg, Huang Yiyun, Brust Peter, Jia Hongmei*. 18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain. Bioorganic & Medicinal Chemistry, 2017, 25: 3792–3802.

7. Li Dan, Chen Yuanyuan, Wang Xia, Deuther-Conrad Winnie, Chen Xin, Jia Bing, Dong Chengyan, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. 99mTc-cyclopentadienyl tricarbonyl chelate-labeled compounds as selective sigma-2 receptor ligands for tumor imaging. Journal of Medicinal Chemistry, 2016, 59: 934-946.

8. Xie Fang, Bergmann Ralf, Kniess Torsten, Deuther-Conrad Winnie, Mamat Constantin, Neuber Christin, Liu Boli, Steinbach Jörg, Brust Peter, Pietzsch Jens, Jia Hongmei*.18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: synthesis and biological evaluation of a s1 receptor radioligand with low lipophilicity as potent tumor imaging agent. Journal of Medicinal Chemistry, 2015, 58, 5395-5407.

9. Xie Fang, Kniess Torsten, Neuber Christin, Deuther-Conrad Winnie, Mamat Constantin, Lieberman Brian P., Liu Boli, Mach Robert H., Brust Peter, Steinbach Jörg, Pietzsch Jens, Jia Hongmei*. Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity. MedChemComm, 2015, 6, 1093-1103.

10. Wang Xia, Li Dan, Deuther-Conrad Winnie, Lu Jie, Xie Ying, Jia Bing, Cui Mengchao, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. Journal of Medicinal Chemistry, 2014, 57, 7113-7125.

11. Chen Yuan-Yuan, Wang Xia, Zhang Jin-Ming, Deuther-Conrad Winnie, Zhang Xiao-Jun, Huang Yiyun, Li Yan, Ye Jia-Jun, Cui Meng-Chao, Steinbach Joerg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising s1 receptor imaging agent. Bioorganic & Medicinal Chemistry, 2014, 22: 5270–5278.

12. Li Yan, Wang Xia, Zhang Jinming, Deuther-Conrad Winniw, Xie Fang, Zhang Xiaojun, Liu Jian, Qiao Jinping, Cui Mengchao, Steinbach Joerg, Brust Peter, Liu Boli, Jia Hongmei*. Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging. Journal of Medicinal Chemistry, 2013, 56, 3478-3491.