邢国文

个人简介

教授，博士生导师，博士（北京大学），博士后（中科院上海有机所、美国Polytechnic大学、美国Scripps研究所）

通信地址：北京市新街口外大街19号， 北京师范大学化学学院

邮编：100875

电子邮箱：gwxing@bnu.edu.cn

课题组主页：http://chem1.bnu.edu.cn/xingguowen

讲授课程

本科生：有机化学IIA（双语）、化学综合设计实验、普通化学

研究生：合成实验、高等有机合成

研究兴趣

生物有机化学：（1）具有生物活性的复杂糖缀合物的全合成；（2）新型荧光探针分子的合成与应用；（3）酶催化反应与酶的高效检测

代表性论文

1. Guang-jian Liu, Li-yan Jia, Guo-wen Xing*, Probing Sialidases or Siglecs with Sialic Acid Analogues, Clusters and Precursors Asian J. Org. Chem., 2020, 9, 42-52.

2. Li-yan Jia, Guang-jian Liu, Yan-ming Ji, Yuan Zhang, Guo-wen Xing*, Assembly of Water-Soluble Sugar-Coated AIE-Active Fluorescent Organic Nanoparticles for the Detection of Ginsenosides Based on Carbohydrate-Carbohydrate Interactions Chemnanomat, 2020, 6, 368-372.

3. Xiao-xiao Niu, Qin-chao Xu, An-zhen Li, Yang-jie Li, Xiao-tai Zhang, Yuan Zhang*, Guo-wen Xing*, A BODIPY-carbazole hybrid as a fluorescent probe: the design, synthesis, and discrimination of surfactants and the determination of the CMC values Analyst, 2019, 144, 6866-6870.

4. Yan-ming Ji, Guang-jian Liu, Cui-yun Li, Yi-chen Liu, Min Hou, Guo-wen Xing*, Water-soluble Glucosamine-coated AIE-Active Fluorescent Organic Nanoparticles: Design, Synthesis and Assembly for Specific Detection of Heparin Based on Carbohydrate-Carbohydrate Interactions Chem. Asian J., 2019, 14, 3295-3300.

5. Guang-jian Liu, Yuan Zhang, Lingyun Zhou, Li-yan Jia, Guohua Jiang, Guo-wen Xing*, Shu Wang, A water-soluble AIE-active polyvalent glycocluster: design, synthesis and studies on carbohydrate-lectin interactions for visualization of Siglec distributions in living cell membranes Chem. Commun., 2019, 55, 9869-9872.

6. Zhang-wei Ning, Song-ze Wu, Guang-jian Liu, Yan-ming Ji, Li-yan Jia, Xiao-xiao Niu, Rong-fang Ma, Yuan Zhang*, Guo-wen Xing*, Water-soluble AIE-Active Fluorescent Organic Nanoparticles: Design, Preparation and Application for Specific Detection of Cysteine over Homocysteine and Glutathione in Living Cells Chem. Asian J., 2019, 14, 2220-2224.

7. Guang-jian Liu, Beihan Wang, Yuan Zhang, Guo-wen Xing*, Xiaoli Yang* and Shu Wang A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis. Chem. Commun., 2018, 54, 10691-10694.

8. Guang-jian Liu, Cui-yun Li, Xiao-tai Zhang, Wei Du, Zhen-yuan Gu, Guo-wen Xing* Modulation of the stereoselectivity and reactivity of glycosylation via (p-Tol)2SO/Tf2O preactivation strategy: From O-, C-sialylation to general O-, N-glycosylation. Chin. Chem. Lett. 2018, 29, 1-10. (编辑约稿)

9. Guang-jian Liu, Sheng-nan Tian, Cui-yun Li, Guo-wen Xing*, Lei Zhou* AIE Materials with Different Electric Charges as Artificial Tongue: Design, Construction, and Assembly with Various Pathogenic Bacteria for Effective Bacterial Imaging and Discrimination. ACS Appl. Mater. Interfaces 2017, 9, 28331-28338.

10. Xiao-tai Zhang, Shu Wang, Guo-wen Xing* Boronlectin/polyelectrolyte ensembles as an artificial tongue: design, construction and application for discriminative sensing of complex glycoconjugates from panax ginseng. ACS Appl. Mater. Interfaces 2017, 9, 3368-3375.

11. Hai-juan Lv, Xiao-tai Zhang, Shu Wang, Guo-wen Xing* Assembly of BODIPY-carbazole dyes with liposomes to fabricate fluorescent nanoparticles for lysosomal bioimaging in living cells. Analyst, 2017, 142, 603-607.

12. Xiao-tai Zhang, Shu Wang, Guo-wen Xing* Aggregates-Based Boronlectins with Pyrene as Fluorophore: Multichannel Discriminative Sensing of Monosaccharides and Their Applications. ACS Appl. Mater. Interfaces, 2016, 8, 12007-12017.

13. Guang-Jian Liu, Zi Long, Hai-juan Lv, Cui-yun Li, Guo-wen Xing* A dialdehyde–diboronate-functionalized AIE luminogen: design, synthesis and application in the detection of hydrogen peroxide. Chem. Commun., 2016, 52, 10233-10236.

14. Xiao-tai Zhang, Shu Wang, Guo-wen Xing* Novel Boronlectins Based on Bispyridium Salt with a Flexible Linker: Discriminative Sensing of Lactose and Other Monosaccharides and Disaccharides in Aqueous Solution, Chem. Asian J., 2015, 10, 2594-2598.

15. Xiao-tai Zhang, Zhen-yuan Gu, Libing Liu, Shu Wang, Guo-wen Xing* Synthesis and labeling of alpha-(2,9)-trisialic acid with cyanine dyes for imaging of glycan-binding receptors on living cells, Chem. Commun., 2015, 51, 8606-8609.

16. Guang-jian Liu, Xiao-tai Zhang, Guo-wen Xing* A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor, Chem. Commun., 2015, 51, 12803-12806.