付化龙

个人简介

讲师，硕士生导师，理学博士（北京师范大学），博士后（哈佛医学院麻省总医院）。

通信地址：北京市新街口外大街19号， 北京师范大学化学学院816室

邮编：100875

电子邮箱：fuhualong@bnu.edu.cn

教育和工作经历

2024.07-至今， 北京师范大学化学学院， 药物化学与分子工程， 副教授

2019.12-2024.06， 北京师范大学化学学院， 药物化学与分子工程， 讲师

2017.11-2019.11， 哈佛医学院/麻省总医院， 放射性药物化学， 博士后

2012.09-2017.06， 北京师范大学化学学院，无机化学， 博士

2008.08-2012.06， 兰州大学核科学与技术学院， 应用化学(放射化学基地班)， 学士

招生信息

每年招收1名硕士生。 欢迎热爱科研、工作认真、积极向上的同学加入。

研究领域

放射性药物化学，Radiopharmaceutical Development focusing on brain imaging and tumour imaging

代表性论文

(1) Wanqing Li, Xiaojun Zhang, Jie Ma, Jingyin Zhou, Xuan Di, Donglan Huang, Kaixiang Zhou, Jinming Zhang,* Lu Wang,* Hualong Fu,* and Mengchao Cui, Preclinical evaluation of dihydropyrazole-cored positron emission tomography (PET) ligands for imaging of receptor-interacting serine/threonine protein kinase 1 (RIPK1) in the brain, J. Med. Chem. 2024, 10.1021/acs.jmedchem.4c01263.

(2) Wanqing Li, Xiaojun Zhang, Jingyin Zhou, Xuan Di, Donglan Huang, Jie Ma, Kaixiang Zhou, Jinming Zhang,* Lu Wang,* Hualong Fu,* and Mengchao Cui, Structure-based discovery of a 4,5-dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain,Eur. J. Med. Chem. 2024, https://doi.org/10.1016/j.ejmech.2024.116803.

(3) Wanqing Li,# Yuqing Qiao,# Jiahui Chen, Yinlong Li, Xiaoyu Du, Steven H. Liang, Hualong Fu*, Visualizing reactive astrocytes: Positron emission tomography imaging ligands for imidazoline-2 binding sites, VIEW, 2023, 20230037.

(4) Hualong Fu, Jian Rong, Zhen Chen, Jingyin Zhou, Thomas Collier, and Steven H. Liang*, Positron emission tomography (PET) imaging tracers for serotonin receptors, J. Med. Chem. 2022, 65, 10755−10808.

(5) Nan Yue, # Hualong Fu,*,# Yimin Chen, Xi Gao, Jiapei Dai, and Mengchao Cui, Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-β plaques in Alzheimer’s disease, Eur. J. Med. Chem. 2022, 243, 114715.

(6) Qi Zeng, Yimin Chen, Yingying Yan, Rong Wan, Yanjing Li, Hualong Fu,* Yu Liu, Sen Liu,* Xiao-Xin Yan, and Mengchao Cui*, D-pi-A-based trisubstituted alkenes as environmentally sensitive fluorescent probes to detect lewy pathologies, Anal. Chem. 2022, 94, 15261−15269.

(7) Hualong Fu, Zhen Chen, Lee Josephson, Zijing Li,* and Steven H. Liang*, Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N‐Methyl‐D‐aspartate (NMDA), α‐Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors, J. Med. Chem. 2019, 62, 403−419.

(8) Hualong Fu; Weiting Tang; Zhen Chen; Vasily V. Belov; Genwei Zhang; Tuo Shao; Xiaofei Zhang; Qingzhen Yu; Jian Rong; Xiaoyun Deng; Wei Han; Scott J. Myers; Pilar Giffenig; Lu Wang; Lee Josephson; Yihan Shao; April T. Davenport; James B. Daunais; Mikhail Papisov; Hongjie Yuan; Zijing Li*; Stephen F. Traynelis*; Steven H. Liang* Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem. Neurosci. 2019, 10, 2263−2275.

(9) 付化龙，周婧茵，一类靶向于CSF1R激酶的苯基酰胺类化合物及其应用，专利号: ZL202410445892.X.